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. 2019 Dec 15;8(12):1642. doi: 10.3390/cells8121642

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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END and ENL induce migration and wound-healing in ER positive breast cancer cells. Pictorial (A) and graphical (B) representation of spheroid migration assay, MCF7, BT474, and T47D spheroids were formed on agarose followed by treatment with 1 μM END and 1 μM ENL. Statistically significant increase in rate of migration was observed. (C) MCF7 cells were treated with 1 μM END, 1 μM ENL and 100 nM E2 and wound healing was observed at regular intervals as indicated. (D,E) MCF7 and T47D cells were treated with 1 μM END, 1 μM ENL, 1 μM tamoxifen alone and in combination followed by cell viability and clonogenicity assay. END and ENL treatment reduced the effectiveness of tamoxifen. * p < 0.05; ** p < 0.005; ^ns p > 0.05.