Figure 1.

Anatomy of the eye and trabecular meshwork: (A) Eye diagram showing anterior chamber between the iris and the cornea, the ciliary body that produces aqueous humor, the lens, and the optic nerve. (B) Aqueous humor (red arrows) produced by the ciliary body flows between the lens and iris into the anterior chamber before leaving the eye through the trabecular meshwork (asterisk). (C) Schematic of the trabecular meshwork and Schlemm’s canal: Aqueous humor flows from the anterior chamber through the 3 layers of the trabecular meshwork called uveoscleral meshwork (UM), corneoscleral meshwork (CM), and the juxtacanalicular tissue (JCT). Aqueous humor (arrow) then crosses the basement membrane (BM) of Schlemm’s Canal either paracellularly or transcellularly and enters into Schlemm’s Canal.