Table 7.
MiRNAs associated with apoptosis in TNBC.
| MiRNA | Direct/Indirect Targets | Functions | Reference |
|---|---|---|---|
| Oncogenic miRNAs | |||
| miR-21 | PTEN | Promotes the tumor proliferation and inhibits cell apoptosis | [90] |
| miR-182 | PFN1, RIP1 | Promote the tumor proliferation, inhibit cell apoptosis and migration | [115,168] |
| miR-301b | CYLD | Inhibits cell apoptosis induced by 5-FU | [169] |
| miR-155-5p | FOXO3A | Promotes proliferation and reduces bufalin-induced apoptosis | [170] |
| miR-17-5p/20a | DR4/DR5 | Inhibit apoptosis | [171] |
| miR-429 | XIAP | Regulates apoptosis | [172] |
| Oncosuppressor miRNAs | |||
| miR-200c | XIAP | Induces apoptosis | [126] |
| miR-31 | Bcl-2, PKCε | Induce apoptosis, increase sensitivity of chemo- and radiosensitivity | [173] |
| miR-4458 | SOCS1 | Inhibits proliferation and promotes apoptosis | [174] |
| miR-890 | CD147 | Inhibits the cell proliferation and invasion, induces apoptosis | [175] |
| miR-509 | TNF-α | Increases apoptosis and inhibits invasion | [176] |
| miR-145 | cIAP1 | Promotes TNF-α-induced apoptosis | [177] |
| miR-199a-5p | TGF-β2, PIK3CD | Proliferate inhibition, cell cycle arrest, and increase apoptosis | [83] |
| miR-1296 | CCND1 | Suppresses proliferation, cell cycle arrest accompanied by induction of apoptosis | [178] |
| miR-10a | PIK3CA | Inhibits the proliferation and migration, promotes apoptosis | [179] |