Table 1.
Relative hAAT protein expression in PiZ mice liver after UFC1 treatment.
| Liver hAAT Protein Expression | Treatment Period | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Two Weeks | One Month | Three Months | |||||||
| Control (n = 6) |
UFC1 (n = 6) |
p Value | Control (n = 5) |
UFC1 (n = 6) |
p Value | Control (n = 7) |
UFC1 (n = 7) |
p Value | |
| hAAT polymer (IHC) | 1 ± 0.1 | 1.1 ± 0.1 | 0.6 | 1 ± 0.1 | 0.9 ± 0.1 | 0.9 | 1 ± 0.04 | 0.8 ± 0.1 | 0.04 |
| Soluble hAAT protein (WB) | 1 ± 0.1 | 0.9 ± 0.1 | 0.5 | 1 ± 0.01 | 0.9 ± 0.01 | 0.02 | 1 ± 0.1 | 0.6 ± 0.1 | 0.03 |
| Insoluble hAAT protein (WB) | 1.2 ± 0.2 | 1 ± 0.2 | 0.7 | 1 ± 0.01 | 0.9 ± 0.01 | 0.02 | 1 ± 0.1 | 0.7 ± 0.1 | 0.007 |
Data are presented as mean ± SEM. hAAT, human alpha1-antitrypsin; IHC, immunohistochemistry; WB, Western blot.