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. 2019 Dec 17;8(12):1655. doi: 10.3390/cells8121655

Figure 1.

Figure 1

A schematic diagram depicting the two modes of STX16 action in autophagy. (A). Syntaxin 16 (STX16) could function at a trans-Golgi network (TGN)-endosomal phagophore formation site to facilitate trafficking of ATG9a-containing vesicles from the recycling endosome, in conjunction with SNARE partners VAMP7 and SNAP-47. (B) STX16 could function in autophagosome–lysosome fusion, potentially replacing STX17. PM—plasma membrane; EE—early endosome; RE—recycling endosome; Phg—phagophore; TGN—trans-Golgi network; Golgi—Golgi apparatus; ER—endoplasmic reticulum; AP—autophagosome; L—lysosome.