Figure 2.

The butterfly effect of RNA alterations on transcriptomic equilibrium. The different modifications affecting either target RNAs or miRNAs and/or both, such as genetic modification (A), alternative polyadenylation (APA) (B), RNA methylation (C), RNA editing (D), and isomiR production (E). Ovals represent the miRNA response elements (MREs); double-headed arrows represent bi-directional regulation in which the thickness indicates the strength of the regulation; single-headed arrows indicate increase (pointed up) or decrease (pointed down) in RNA expression; red stars indicate non-specific nucleotide alteration; grey crosses indicate loss of interaction; red lightning bolts represent mutation events; yellow circles with an A represent methylation marks; grey circle with an I represents A-to-I RNA editing.