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. 2019 Dec 2;8(12):1556. doi: 10.3390/cells8121556

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Periportalization of CCl₄ exposed liver tissue. A. Enrichment of pericentral and periportal genes among genes up or downregulated by CCl₄ exposure. B. Summarized results of Gene Set Enrichment Analysis (GSEA) showing normalized enrichment score (NES) and p-values. C. Leading edge of periportal and pericentral gene set that mainly accounts for the enrichment score of the gene set. The color scheme indicates the logFC. D. Selection of GO-terms and TFs that characterize the overlap of CCl₄ signature and pericentral/periportal gene sets.