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. 2020 Jan 9;20:19. doi: 10.1186/s12886-019-1285-9

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Anterior segment photographs of patients on vandetanib and osimertinib. Corneal photographs of case 2 taken at 419 days after the start of chemotherapy with vandetanib. a Both corneas showed dense cornea verticillata on the central part (yellow arrows Δ). b Under fluorescein staining, no corneal epithelial defects were found. Corneal photographs of case 4 taken at 305 days after start of chemotherapy with osimertinib. c Vortex keratopathy with a whorl-like pattern was prominent, especially on the patient’s right cornea (yellow arrows Δ). d Under fluorescein staining, no corneal epithelial defects were found