Table 1.

Ocular complications of patients who underwent EGFR of FGFR inhibitors chemotherapy

	External adnexa					Internal Adnexa			non specifici	Total
	orbita	eyelidb	sclera / conjunctivac	extraocular musclesd	corneae	lensf	vitreous/retinag	optic disch
Disease-unrelated	5	107	29	48	101	189	215	118	300	1112
Disease-related	5	–	–	–	–	–	28	–	–	33
Treatment-related	–	–	–	–	13	–	3	–	–	16
Total	10	107	29	48	114	189	246	118	300	1161

Patients were categorized into three groups and subdivided according to their clinical diagnosis. Three groups were 'Disease-unrelated', 'Disease-related' and 'Treatment-related' group

^aDisease-unrelated (blow out fracture), Disease-related (orbit metastasis)

^bDisease-unrelated (meibomian gland dysfunction, blepharitis, nasolacrimal duct obstruction, ptosis, dermatochalasis, cellulitis, eyelid cancer, entropion, chlazion, trichiasis)

^cDisease-unrelated (allergic conjunctivitis, viral conjunctivitis)

^dDisease-unrelated (strabismus)

^eDisease-unrelated (dry eye syndrome, opacity, scar, pseudophakic bullous keraopathy, dystrophy, herpetic keratitis, exposure keratitis, epidermic keratoconjuncitivitis), Treatment-related (corneal epithelial changes, corneal ulcer)

^fDisease-unrelated (cataract)

^gDisease-unrelated (diabetic retinopathy, macular hole, epiretinal membrance, myopic tractional maculopathy, central serous chorioretinopathy, retinal detachmentage related macular degeneration, vitreous floater, endophthalmitis), Disease related (choroidal metastasis), Treatment-related (radiation retinopathy)

^hDisease-unrelated (glaucoma, optic neuropathy, visual field defect)

ⁱThis category includes patients who had regular ophthalmologic examination without any specific lesions