Table 1.

Effects of ZIKV NS5 and infection on host immune responses.

NS5 Expression
Cell Type	Effect	Citation
293/293T	Inhibits ISRE-luc signaling	[67]
	Inhibits ISG54-luc signaling	[26]
	Blocks type I IFN-induced STAT1 phosphorylation	[39]
	Antagonizes type I IFN production	[40]
A549	Antagonizes type I IFN production	[75]
LN229	Activates pro-inflammatory genes	[21]
ZIKV Infection
Cell Type	Effect	Citation
DCs	Inhibits type I IFN signaling	[76]
293T	Inhibits type I IFN signaling	[26]
Dendritic cells	Inhibits type I IFN induced STAT1 and STAT2 phosphorylation	[75]
JEG3 SF268	Activates STAT1-mediated type II IFN and pro-inflammatory pathways	[25]
LN229	Induces STAT1 phosphorylation and activation of pro-inflammatory genes	[21]
Brain Microglia	Induces inflammation	[77]
Retina Pigment Epithelial	Induces inflammatory response	[76]