Table 2.
Summary of organs in which ZIKV infection leads to an inflammatory response and/or pathology in cell culture (grey), animal models (green) and human samples (blue). Y denotes a positive finding while N means it was not demonstrated in the cited paper.
| Organ | Cell/Tissue Type | Inflammatory Response | Pathology | Citation |
|---|---|---|---|---|
| Brain | SF268 | Y | N | [25] |
| LN229 | Y | N | [21] | |
| Brain Microglia | Y | N | [77] | |
| NPCs | N | Y | [93] | |
| NPCs | Y | N | [81] | |
| Neurospheres/Organoids | N | Y | [94] | |
| Brain | N | N | [86] | |
| Brain | N | N | [95] | |
| Eye | Retina Pigment Epithelial | Y | N | [76] |
| Eye | N | N | [82] | |
| Conjunctival fluid | N | N | [88] | |
| Male Reproductive Tract | Sertoli | N | N | [96] |
| Testis | Y | Y | [85] | |
| Testis | N | N | [86] | |
| Testis | N | Y | [84] | |
| Sperm/Semen | N | N | [91,92] | |
| Female Reproductive Tract | JEG3 | Y | N | [25] |
| Uterine fibroblasts | N | N | [28] | |
| Ovary | Y | N | [97] | |
| Cervical mucus | N | N | [89] | |
| Vagina secretions | N | N | [90] | |
| Placenta | N | N | [95] |