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. 2020 Jan 9;18:7. doi: 10.1186/s12964-019-0502-8

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — FOXE1 repressed glycolysis in CRC cells. a, b Attenuated FOXE1 expression promotes glucose uptake (a) and lactate proguction (b) in SW480 and HT29 cells. c and d Enforced expression of FOXE1 inhibits glucose uptake (c) and lactate proguction (d) in HCT116 and LoVo cells. e and f ECAR value increased significantly in FOXE1 silenced SW480 cell (e) but decreased in FOXE1 over-expressed HCT116 cell (f). g and h OCR value decreased significantly in FOXE1 silenced SW480 cell (g) but increased in FOXE1 over-expressed HCT116 cell (h). *P < 0.05