Fig. 8.
Silence of HK2 inhibited cell growth and glycolysis in CRC cells. a Validation of attenuated-expression HK2 in HCT116 and LoVo using western blotting and qRT-PCR. b, c and d. The impact of HK2 expression on cell proliferation (b), colony formation (c) and cell cycle (d). e and f. Silence of HK2 inhibited glucose uptake and lactate production. g, h and i. HCT116-NC and HCT116-FOXE1-KD#1 were subcutaneously injected into the right and left forelimb of five nude mice (5 × 106 cells each xenograft). Gross xenografts (g), tumor growth curves (h) and tumors weights (i) are shown. *P < 0.05