Figure 5.
A. Demographics and baseline characteristics of the PPMI cohort who were administered the Montreal Cognitive Assessment (MoCA). All values are represented as median (IQR) unless otherwise specified. Race is not reported for N=7 subjects. B and C. Effects of TMEM106B genotype on longitudinal MoCA performance in Parkinson’s disease patients, assessed with linear mixed effects models adjusting for age, sex, and baseline MoCA. In panel B, predicted MoCA scores are shown by TMEM106B genotype, indicated by color, and bands represent 95% confidence intervals. In panel C, coefficients (β), standard error (SE), and p-values (two-sided/one-sided) for TMEM106B genotype*time interaction shown, with time in years.