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. 2019 Jul 10;18(2):337–353. doi: 10.1111/pbi.13201

Figure 12.

Figure 12

A working model illustrating that MdMYB308L functions in cold stress response and anthocyanin accumulation. MdMYB308L interacts with MdbHLH33 to increase its transcriptional activity and enhance its binding to the MdCBF2 and MdDFR promoters, thus promoting cold tolerance and anthocyanin accumulation. In the absence of cold stress, MdMIEL1 interacts with MdMYB308L to ubiquitinate and degrade it, thus negatively regulating MdMYB308L‐promoted cold tolerance and anthocyanin accumulation. On one hand, cold stress up‐regulates the transcription of MdMYB308L, which promotes the cold tolerance and anthocyanin accumulation. On the other hand, cold stress inhibited MdMIEL1 expression, thus to release the MdMIEL1‐enhanced protein degradation of MdMYB308L, which also contributes to cold tolerance and anthocyanin accumulation. 26S proteasome represents that MdMYB308L undergoes 26S proteasome‐mediated degradation by MdMIEL1. The green line represents transcriptional regulation. The blue line represents post‐translational regulation. The red line represents transcriptional and post‐translational regulations.