Husain 2017.

Methods	RCT
Participants	Inclusion: age 20 to 40 years, singleton pregnancy, cephalic presentation ≥ 37 weeks Exclusion: BS of > 4, cephalopelvic disproportion on examination, history of placenta previa or unexplained vaginal bleeding, history of previous CS or other uterine surgery, active herpes simplex infection, chorioamnionitis, contraindication to use of PGs, acute pelvic inflammatory disease, contraindication to vaginal delivery, a non reassuring FHR pattern prior to induction.
Interventions	Oral misoprostol (n = 157): 50 mcg, every 4 hours, max 4 gifts Foley catheter + oral misoprostol (n = 161): 16 or 18F, filled with 30 mL + oral misoprostol (50 mcg) every 4 hours, max 4 gifts both groups: if labour was not established within 4 hours of the 4th dose of misoprostol, induction was considered to have failed and such cases were then delivered by CS.
Outcomes	Failure to achieve vaginal delivery after 24 hours, induction‐to‐delivery interval, mode of delivery, reason for CS maternal complications, NICU admissions
Notes	Setting: Abbasi Shaheed Hospital in Karachi, Pakistan, tertiary care centre Study period: May 2016 to October 2016. Funding: no funding reported Declarations of interest: none declared
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated sequence, block randomisation
Allocation concealment (selection bias)	Low risk	Sequentially‐numbered opaque, sealed envelopes
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not feasible due to nature of intervention
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	High risk	ITT analysis not reported, cases excluded because of protocol violation. no missing data or cases
Selective reporting (reporting bias)	Low risk	All pre‐specified outcomes were reported in results
Other bias	Low risk	No other bias detected