Perry 1998.

Methods	RCT.
Participants	Inclusion: singleton gestation, cephalic presentation, BS of ≤ 4. Exclusion: spontaneous uterine contractions, rupture of membranes, placenta previa, unexplained vaginal bleeding, a non‐reactive nonstress test, an EFW > 4500 g, a prior vertical uterine incision, parity of > 5, active genital herpes infection, or a contraindication to receiving PGs
Interventions	Vaginal misoprostol 25 mcg every 4 hours (65 women) intracervical Foley of 50cc and PGE2 (4 mg) every 4 hours (62 women)
Outcomes	CS, instrumental delivery, uterine hyperstimulation, AS, NICU admission, chorioamnionitis, perinatal death.
Notes	Setting: University of Mississippi Medical Center Labor and Delivery Unit, Jackson, USA Study period: August 1996 ‐ April 1997 Funding: not reported Declarations of interest: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated random schedule.
Allocation concealment (selection bias)	Low risk	The allocation of assignment was concealed by placement in a numbered, opaque, sealed envelope
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not feasible due to nature of intervention
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	ITT not reported, although this is likely as numbers are equal to randomised numbers. No missing cases or data in outcomes of interest
Selective reporting (reporting bias)	Low risk	All pre‐specified outcomes were reported
Other bias	Low risk	No other bias detected