Skip to main content
. 2019 Oct 18;2019(10):CD001233. doi: 10.1002/14651858.CD001233.pub3

Sheikher 2009.

Methods RCT
Participants Inclusion: 1st or 2nd gravida, single, live fetus, cephalic, indication for IOL, GA 37‐42 weeks, BS ≤ 5, absence of uterine contractions.
Exclusion: previous uterine surgery, non reassuring FHR tracing, IUGR, oligohydramnios, placenta praevia, multifetal pregnancy, chorioamnionitis, active herpes, EFW > 4 kg, renal or hepatic disease
Interventions 1. Oral misoprostol (n = 30):, 50 mcg, repeated every 4 hours to a max of 5 doses.
2. Vaginal misoprostol (n = 30): 25 mcg, repeated every 4 hours to a max of 5 dosis. n = 30
3. Foley catheter (n = 30): 16 or 18 F, 35 mL. max of 16 hours
In all 3 groups after 16 hours oxytocin was started.
Outcomes interval from induction to birth, mode of delivery, maternal complication, neonatal outcome, failed induction
Notes Setting: SMGS hospital, Jammu, India
Study period: over 1 year
Funding: not reported
Declarations of interest: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Random assigned, no more information reported
Allocation concealment (selection bias) Unclear risk Not reported
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Not feasible due to nature of intervention
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not reported
Incomplete outcome data (attrition bias) 
 All outcomes High risk No ITT reported, cases missing in table 2, not clear why
Selective reporting (reporting bias) High risk No outcome measures were mentioned in the method section, induction to delivery interval is given but no SDs,
Other bias Low risk No other bias detected