Comparison 2. Fish oil lipid emulsion (LE) vs another fish oil LE (see Appendix 3).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Days to regain birth weight	1	55	Mean Difference (IV, Fixed, 95% CI)	2.0 [‐0.64, 4.64]
1.1 MOFS‐LE vs MFS‐LE	1	55	Mean Difference (IV, Fixed, 95% CI)	2.0 [‐0.64, 4.64]
2 Growth rate (g/kg/day)	1	55	Mean Difference (IV, Fixed, 95% CI)	4.0 [‐2.03, 10.03]
2.1 MOFS‐LE vs MFS‐LE	1	55	Mean Difference (IV, Fixed, 95% CI)	4.0 [‐2.03, 10.03]
3 Parenteral nutrition‐associated liver disease (PNALD)/cholestasis (conjugated bilirubin ≥ 2 mg/dL)	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.06, 14.65]
3.1 MOFS‐LE vs MFS‐LE	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.06, 14.65]
4 PNALD/cholestasis (any definition)	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.06, 14.65]
4.1 MOFS‐LE vs MFS‐LE	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.06, 14.65]
5 Death before discharge	1	60	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.15, 6.64]
5.1 MOFS‐LE vs MFS‐LE	1	60	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.15, 6.64]
6 Chronic lung disease (oxygen requirement at 36 weeks)	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.40, 3.35]
6.1 MOFS‐LE vs MFS‐LE	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.40, 3.35]
7 Any sepsis (clinical or culture positive (or both))	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	1.69 [0.56, 5.11]
7.1 MOFS‐LE vs MFS‐LE	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	1.69 [0.56, 5.11]
8 Necrotising enterocolitis (≥ stage 2)	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	2.90 [0.12, 68.15]
8.1 MOFS‐LE vs MFS‐LE	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	2.90 [0.12, 68.15]
9 Any patent ductus arteriosus	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.55, 1.69]
9.1 MOFS‐LE vs MFS‐LE	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.55, 1.69]
10 Conjugated bilirubin levels (µmol/L)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
10.1 MOFS‐LE vs MFS‐LE	1	55	Mean Difference (IV, Fixed, 95% CI)	‐1.40 [‐6.40, 3.60]