Comparison 6. Fish oil lipid emulsion (LE) vs non‐fish oil LE in preterm infants with cholestasis (see Appendix 3).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Growth rate (g/week)	1	16	Mean Difference (IV, Fixed, 95% CI)	45.0 [15.00, 75.00]
1.1 Pure F‐LE vs S‐LE	1	16	Mean Difference (IV, Fixed, 95% CI)	45.0 [15.00, 75.00]
2 Resolution of parenteral nutrition‐associated liver disease (PNALD)/cholestasis (conjugated bilirubin < 2 mg/dL)	1	16	Risk Ratio (M‐H, Fixed, 95% CI)	5.6 [0.34, 93.35]
2.1 Pure F‐LE vs IL	1	16	Risk Ratio (M‐H, Fixed, 95% CI)	5.6 [0.34, 93.35]
3 PNALD/cholestasis (any definition)	2	40	Risk Ratio (M‐H, Fixed, 95% CI)	0.54 [0.32, 0.91]
3.1 MOFS‐LE vs S‐LE	1	24	Risk Ratio (M‐H, Fixed, 95% CI)	0.39 [0.14, 1.10]
3.2 Pure F‐LE vs S‐LE	1	16	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.43, 1.13]
4 Death before discharge	2	40	Risk Ratio (M‐H, Fixed, 95% CI)	0.24 [0.03, 1.87]
4.1 MOFS‐LE vs S‐LE	1	24	Risk Ratio (M‐H, Fixed, 95% CI)	0.39 [0.02, 8.69]
4.2 Pure F‐LE vs S‐LE	1	16	Risk Ratio (M‐H, Fixed, 95% CI)	0.16 [0.01, 2.88]
5 Any sepsis	2	40	Risk Ratio (M‐H, Fixed, 95% CI)	1.21 [0.50, 2.92]
5.1 MOFS‐LE vs S‐LE	1	24	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [0.52, 4.18]
5.2 Pure F‐LE vs S‐LE	1	16	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.14, 4.23]
6 Hyperglycaemia	1	24	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [0.52, 4.18]
7 Head growth velocity (cm/week)	1	16	Mean Difference (IV, Fixed, 95% CI)	0.16 [‐0.01, 0.33]
7.1 Pure F‐LE vs S‐LE	1	16	Mean Difference (IV, Fixed, 95% CI)	0.16 [‐0.01, 0.33]
8 Conjugated bilirubin levels (µmol/L)	1	24	Mean Difference (IV, Fixed, 95% CI)	‐47.0 [‐71.65, ‐22.35]
8.1 MOFS‐LE vs S‐LE	1	24	Mean Difference (IV, Fixed, 95% CI)	‐47.0 [‐71.65, ‐22.35]