S20	S3 AND S6 AND S9 AND S19
S19	S17 NOT S18
S18	TX animal* NOT TX human*
S17	S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16
S16	TX trial
S15	TX randomly
S14	SU clinical trial
S13	TX placebo
S12	TX randomized
S11	PT clinical trial
S10	PT randomized controlled trial
S9	(TX psychotherapy OR counselling OR behavior* OR contigenc* OR supportive OR reinforcement OR motivation* OR incentive OR "cognitive therapy") AND (S7 OR S8)
S8	TX psychotherapy OR counselling OR behavior* OR contigenc* OR supportive OR reinforcement OR motivation* OR incentive OR "cognitive therapy"
S7	(MH "Psychotherapy+") OR (MH "Psychotherapy, Brief") OR (MH "Psychotherapy, Psychodynamic") OR (MH "Psychotherapy, Group+") OR (MH "Cognitive Therapy+") OR (MH "Equine‐Assisted Therapy")
S6	(TX ( drug OR substance OR alcohol OR marijuana OR cannabis OR meth/dextro‐amphetamine OR amphetamine OR MDMA OR heroin OR narcotic OR opiate OR opioid or opium OR ecstasy OR methadone OR cocaine or psychostimulant* or inhalant* OR solvent* ) AND TX ( abus* OR use* OR misus* OR usin* OR utilis* OR depend* OR addict* OR illegal* OR illicit* OR habit* OR withdraw* OR behavi* OR abstinence* OR abstain* OR intoxica* OR addict* or disorder* )) AND (S4 OR S5)
S5	TX ( drug OR substance OR alcohol OR marijuana OR cannabis OR meth/dextro‐amphetamine OR amphetamine OR MDMA OR heroin OR narcotic OR opiate OR opioid or opium OR ecstasy OR methadone OR cocaine or psychostimulant* or inhalant* OR solvent* ) AND TX ( abus* OR use* OR misus* OR usin* OR utilis* OR depend* OR addict* OR illegal* OR illicit* OR habit* OR withdraw* OR behavi* OR abstinence* OR abstain* OR intoxica* OR addict* or disorder* )
S4	(MH "Substance Use Disorders+") OR (MH "Organic Mental Disorders, Substance‐Induced+") OR (MH "Alcohol‐Related Disorders+")
S3	(TX affective OR depression OR "depressive disorder" OR "mood disorder" OR anxiety OR dysthymic) AND (S1 OR S2)
S2	TX affective OR depression OR "depressive disorder" OR "mood disorder" OR anxiety OR dysthymic
S1	(MH "Affective Disorders+")