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. 2020 Jan 9;8:2. doi: 10.1186/s40364-020-0182-y

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Chemical structure and mechanism of action of IMiDs. a Chemical structure of thalidomide, lenalidomide, pomalidomide, CC-122, CC-885 and CC-220. b IMiDs (purple rhombuses) bind to CRBN, a substrate receptor of CRL4 E3 ligase, to recruit substrates for ubiquitination and proteasomal degradation. Ub, ubiquitin