Source	Search strategy	Hits retrieved
ALOIS (Cochrane Dementia and Cognitive Improvement Group's Specialised Register search via CRS) (Date of most recent search: 5 September 2019)	"animal assisted" AND INREGISTER "animal facilitated" AND INREGISTER cat AND INREGISTER cats AND INREGISTER dog AND INREGISTER dogs AND INREGISTER equine AND INREGISTER "fish tank*" AND INREGISTER hippotherapy AND INREGISTER horse AND INREGISTER pets AND INREGISTER "pet therapy" AND INREGISTER seal AND INREGISTER #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13	Sep 2018: 92 Sep 2019: 13
CENTRAL (the Cochrane Library) crso.cochrane.org/SearchSimple.php (Date of most recent search: 5 September 2019)	#1 MESH DESCRIPTOR Dementia EXPLODE ALL TREES #2 MESH DESCRIPTOR Delirium #3 MESH DESCRIPTOR Wernicke Encephalopathy #4 MESH DESCRIPTOR Neurocognitive Disorders #5 dement*:TI,AB,KY #6 alzheimer*:TI,AB,KY #7 (lewy* adj2 bod*):TI,AB,KY #8 (chronic adj2 cerebrovascular):TI,AB,KY #9 ("organic brain disease" or "organic brain syndrome"):TI,AB,KY #10 ("benign senescent forgetfulness"):TI,AB,KY #11 (cerebr* adj2 deteriorat*):TI,AB,KY #12 (cerebral* adj2 insufficient*):TI,AB,KY #13 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 14917 #14 MESH DESCRIPTOR Animal Assisted Therapy EXPLODE ALL TREES #15 MESH DESCRIPTOR Animals, Domestic EXPLODE ALL TREES #16 MESH DESCRIPTOR Bonding, Human‐Pet EXPLODE ALL TREES #17 MESH DESCRIPTOR Equine‐Assisted Therapy EXPLODE ALL TREES #18 MESH DESCRIPTOR Pets EXPLODE ALL TREES #19 (animal assisted):TI,AB,KY #20 (animal facilitated):TI,AB,KY #21 animal‐assisted:TI,AB,KY #22 animal‐facilitated:TI,AB,KY #23 AAA:TI,AB,KY #24 AAI:TI,AB,KY #25 AAT:TI,AB,KY #26 (Animal Human Bond*):TI,AB,KY #27 (animal visit*):TI,AB,KY #28 (Animal‐Human Bond*):TI,AB,KY #29 aquaria:TI,AB,KY #30 aquarium*:TI,AB,KY #31 cat:TI,AB,KY #32 cats:TI,AB,KY #33 (companion animal*):TI,AB,KY #34 dog:TI,AB,KY #35 dogs:TI,AB,KY #36 equine:TI,AB,KY #37 (Fish tank*):TI,AB,KY #38 hippotherapy:TI,AB,KY #39 horse*:TI,AB,KY #40 (horseback riding therap*):TI,AB,KY #41 (human animal teams):TI,AB,KY #42 (human‐animal teams):TI,AB,KY #43 (pet facilitated therap*):TI,AB,KY #44 (Pet Human Bond*):TI,AB,KY 0 #45 pets:TI,AB,KY #46 pet‐therap*:TI,AB,KY #47 (pet adj5 (therap* or visit* or assist* or robot* or resident* or companion*)):TI,AB,KY #48 (recreational horseback riding therapy):TI,AB,KY #49 (resident cat*):TI,AB,KY #50 dog‐assisted:TI,AB,KY #51 (service animal program*):TI,AB,KY #52 (therapeutic adj3 animal*):TI,AB,KY #53 (visiting animal*):TI,AB,KY #54 #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 OR #44 OR #45 OR #46 OR #47 OR #48 OR #49 OR #50 OR #51 OR #52 OR #53 #55 #13 AND #54	Dec 2018: 101 Sep 2019: 27
MEDLINE In‐process and other non‐indexed citations and MEDLINE 1950‐present (OvidSP) (Date of most recent search: 5 September 2019)	1 exp Dementia/ 2 Delirium/ 3 Wernicke Encephalopathy/ 4 Delirium, Dementia, Amnestic, Cognitive Disorders/ 5 dement*.mp. 6 alzheimer*.mp. 7 (lewy* adj2 bod*).mp. 8 (chronic adj2 cerebrovascular).mp. 9 ("organic brain disease" or "organic brain syndrome").mp. 10 "benign senescent forgetfulness".mp. 11 (cerebr* adj2 deteriorat*).mp. 12 (cerebral* adj2 insufficient*).mp. 13 or/1‐12 14 exp Animal Assisted Therapy/ 15 exp Animals, Domestic/ 16 exp Bonding, Human‐Pet/ 17 exp Equine‐Assisted Therapy/ 18 Pets/ 19 "animal assisted".ti,ab. 20 "animal facilitated".ti,ab. 21 "animal‐assisted".ti,ab. 22 "animal‐facilitated".ti,ab. 23 AAA.ti,ab. 24 AAI.ti,ab. 25 AAT.ti,ab. 26 Animal Human Bond*.ti,ab. 27 animal visit*.ti,ab. 28 Animal‐Human Bond*.ti,ab. 29 aquaria.ti,ab. 30 aquarium*.ti,ab. 31 cat.ti,ab. 32 cats.ti,ab. 33 companion animal*.ti,ab. 34 dog.ti,ab. 35 dogs.ti,ab. 36 equine.ti,ab. 37 Fish tank*.ti,ab. 38 hippotherapy.ti,ab. 39 horse*.ti,ab. 40 horseback riding therap*.ti,ab. 41 human animal teams.ti,ab. 42 human‐animal teams.ti,ab. 43 pet facilitated therap*.ti,ab. 44 Pet Human Bond*.ti,ab. 45 pets.ti,ab. 46 pet‐therap*.ti,ab. 47 (pet adj5 (therap* or visit* or assist* or robot* or resident* or companion*)).ti,ab. 48 recreational horseback riding therapy.ti,ab. 49 resident cat*.ti,ab. 50 dog‐assisted.ti,ab. 51 service animal program*.ti,ab. 52 (therapeutic adj3 animal*).ti,ab. 53 visiting animal*.ti,ab. 54 or/14‐53 55 13 and 54 56 randomized controlled trial.pt. 57 controlled clinical trial.pt. 58 randomized.ab. 59 placebo.ab. 60 drug therapy.fs. 61 randomly.ab. 62 trial.ab. 63 groups.ab. 64 or/56‐63 65 exp animals/ not humans.sh. 66 64 not 65 67 55 and 66	Dec 2018: 249 Sep 2019: 114
EMBASE (OvidSP) 1974 to present (Date of most recent search: 5 September 2019)	1 Dementia/ 2 Delirium/ 3 Wernicke Encephalopathy/ 4 Delirium, Dementia, Amnestic, Cognitive Disorders/ 5 ("benign senescent forgetfulness" or ("normal pressure hydrocephalus" and "shunt*") or ("organic brain disease" or "organic brain syndrome") or ((cerebral* or cerebrovascular or cerebro‐vascular) adj2 insufficien*) or (cerebr* adj2 deteriorat*) or (chronic adj2 (cerebrovascular or cerebro‐vascular)) or (creutzfeldt or jcd or cjd) or (lewy* adj2 bod*) or (pick* adj2 disease) or alzheimer* or binswanger* or deliri* or dement* or huntington* or korsako*).tw. 6 "major neurocognitive disorder".ti,ab. 7 or/1‐6 8 exp animal assisted therapy/ 9 exp domestic animal/ 10 exp human‐animal bond/ 11 exp hippotherapy/ 12 exp pet animal/ 13 animal assisted.ti,ab. 14 animal facilitated.ti,ab. 15 animal‐assisted.ti,ab. 16 animal‐facilitated.ti,ab. 17 AAA.ti,ab. 18 AAI.ti,ab. 19 AAT.ti,ab. 20 Animal Human Bond*.ti,ab. 21 animal visit*.ti,ab. 22 Animal‐Human Bond*.ti,ab. 23 aquaria.ti,ab. 24 aquarium*.ti,ab. 25 cat.ti,ab. 26 cats.ti,ab. 27 companion animal*.ti,ab. 28 dog.ti,ab. 29 dogs.ti,ab. 30 equine.ti,ab. 31 Fish tank*.ti,ab. 32 hippotherapy.ti,ab. 33 horse*.ti,ab. 34 horseback riding therap*.ti,ab. 35 human animal teams.ti,ab. 36 human‐animal teams.ti,ab. 37 pet facilitated therap*.ti,ab. 38 Pet Human Bond*.ti,ab. 39 pets.ti,ab. 40 pet‐therap*.ti,ab. 41 (pet adj5 (therap* or visit* or assist* or robot* or resident* or companion*)).ti,ab. 42 resident cat*.ti,ab. 43 recreational horseback riding therapy.ti,ab. 44 dog‐assisted.ti,ab. 45 service animal program*.ti,ab. 46 (therapeutic adj3 animal*).ti,ab. 47 visiting animal*.ti,ab. 48 or/8‐47 49 7 and 48 50 randomized controlled trial/ 51 controlled clinical trial/ 52 random$.ti,ab. 53 randomization/ 54 intermethod comparison/ 55 placebo.ti,ab. 56 (compare or compared or comparison).ti. 57 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab. 58 (open adj label).ti,ab. 59 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. 60 double blind procedure/ 61 parallel group$1.ti,ab. 62 (crossover or cross over).ti,ab. 63 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. 64 (assigned or allocated).ti,ab. 65 (controlled adj7 (study or design or trial)).ti,ab. 66 (volunteer or volunteers).ti,ab. 67 trial.ti. 68 or/50‐67 69 49 and 68 70 from 69 keep 1‐649	Dec 2018: 649 Sep 2019: 117
PSYCINFO (OvidSP) (Date of most recent search: 5 September 2019)	1 exp Dementia/ 2 exp Delirium/ 3 exp Huntingtons Disease/ 4 exp Kluver Bucy Syndrome/ 5 exp Wernickes Syndrome/ 6 exp Cognitive Impairment/ 7 dement*.mp. 8 alzheimer*.mp. 9 (lewy* adj2 bod*).mp. 10 deliri*.mp. 11 (chronic adj2 cerebrovascular).mp. 12 ("organic brain disease" or "organic brain syndrome").mp. 13 "supranuclear palsy".mp. 14 ("normal pressure hydrocephalus" and "shunt*").mp. 15 "benign senescent forgetfulness".mp. 16 (cerebr* adj2 deteriorat*).mp. 17 (cerebral* adj2 insufficient*).mp. 18 (pick* adj2 disease).mp. 19 (creutzfeldt or jcd or cjd).mp. 20 huntington*.mp. 21 binswanger*.mp. 22 korsako*.mp. 23 ("parkinson* disease dementia" or PDD or "parkinson* dementia").mp. 24 "major neurocognitive disorder".ti,ab. 25 or/1‐24 26 exp Animal Assisted Therapy/ 27 exp Interspecies Interaction/ 28 exp Pets/ 29 exp Horses/ 30 animal assisted.ti,ab. 31 animal facilitated.ti,ab. 32 animal‐assisted.ti,ab. 33 animal‐facilitated.ti,ab. 34 AAA.ti,ab. 35 AAI.ti,ab. 36 AAT.ti,ab. 37 Animal Human Bond*.ti,ab. 38 animal visit*.ti,ab. 39 Animal‐Human Bond*.ti,ab. 40 aquaria.ti,ab. 41 aquarium*.ti,ab. 42 cat.ti,ab. 43 cats.ti,ab. 44 companion animal*.ti,ab. 45 dog.ti,ab. 46 dogs.ti,ab. 47 equine.ti,ab. 48 Fish tank*.ti,ab. 49 hippotherapy.ti,ab. 50 horse*.ti,ab. 51 horseback riding therap*.ti,ab. 52 human animal teams.ti,ab. 53 human‐animal teams.ti,ab. 54 pet facilitated therap*.ti,ab. 55 Pet Human Bond*.ti,ab. 56 pets.ti,ab. 57 pet‐therap*.ti,ab. 58 (pet adj5 (therap* or visit* or assist* or robot* or resident* or companion*)).ti,ab. 59 recreational horseback riding therapy.ti,ab. 60 resident cat*.ti,ab. 61 dog‐assisted.ti,ab. 62 service animal program*.ti,ab. 63 (therapeutic adj3 animal*).ti,ab. 64 visiting animal*.ti,ab. 65 or/26‐64 66 25 and 65 67 exp Clinical Trials/ 68 randomly.ab. 69 randomi?ed.ti,ab. 70 placebo.ti,ab. 71 groups.ab. 72 "double‐blind*".ti,ab. 73 "single‐blind*".ti,ab. 74 RCT.ti,ab. 75 or/67‐74 76 66 and 75 77 from 76 keep 1‐101	Dec 2018: 101 Sep 2019: 7
CINAHL (EBSCOhost) (Date of most recent search: 5 September 2019)	S74 S60 AND S73 S73 S61 OR S62 OR S63 OR S64 OR S65 OR S66 OR S67 OR S68 OR S69 OR S70 OR S71 OR S72 S72 MH "Random Assignment" S71 MH "Single‐Blind Studies" or MH "Double‐Blind Studies" or MH "Triple‐Blind Studies" S70 MH "Crossover Design" S69 MH "Factorial Design" S68 MH "Placebos" S67 MH "Clinical Trials" S66 TX "multi‐centre study" OR "multi‐center study" OR "multicentre study" OR "multicenter study" OR "multi‐site study" S65 TX crossover OR "cross‐over" S64 AB placebo* S63 TX random* S62 TX trial* S61 TX "latin square" S60 S20 AND S59 S59 S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 OR S43 OR S44 OR S45 OR S46 OR S47 OR S48 OR S49 OR S50 OR S51 OR S52 OR S53 OR S54 OR S55 OR S56 OR S57 OR S58 S58 TX visiting animal* S57 TX therapeutic N3 animal* S56 TX service animal program* S55 TX dog‐assisted S54 TX resident cat* S53 TX recreational horseback riding therapy S52 TX pet N5 (therap* or visit* or assist* or robot* or resident* or companion*) S51 TX pet‐therap* S50 TX pets S49 TX Pet Human Bond* S48 TX pet facilitated therap* S47 TX human‐animal teams S46 TX human animal teams S45 TX horseback riding therap* S44 TX horse* S43 TX hippotherapy S42 TX Fish tank* S41 TX equine S40 TX dogs S39 TX dog S38 TX companion animal* S37 TX cats S36 TX cat S35 TX aquarium* S34 TX aquaria S33 TX Animal Human Bond* S32 TX AAT S31 TX AAI S30 TX AAA S29 TX animal‐facilitated S28 TX animal‐assisted S27 TX animal facilitated S26 TX animal assisted S25 (MH "Pets") S24 (MH "Equine‐Assisted Therapy") S23 (MH "Human‐Pet Bonding") S22 (MH "Animal Assisted Therapy (Iowa NIC)") S21 (MH "Pet Therapy+") S20 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 S19 TX "major neurocognitive disorder" S18 TX korsako* S17 TX binswanger* S16 TX huntington* S15 TX creutzfeldt or jcd or cjd S14 TX pick* N2 disease S13 TX cerebral* N2 insufficient* S12 TX cerebr* N2 deteriorat* S11 TX "benign senescent forgetfulness" S10 TX "normal pressure hydrocephalus" and "shunt*" S9 TX "organic brain disease" or "organic brain syndrome" S8 TX chronic N2 cerebrovascular S7 TX deliri* S6 TX lewy* N2 bod* S5 TX alzheimer* S4 TX dement* S3 MH "Wernicke's Encephalopathy" S2 (MH "Delirium") or (MH "Delirium, Dementia, Amnestic, Cognitive Disorders") S1 (MH "Dementia+")	Dec 2018: 388 Sep 2019: 76
Web of Science – core collection (ISI Web of Science) (Date of most recent search: 5 September 2019)	TOPIC: (dement* OR alzheimer* OR "vascular cognitive impairment" OR "lew* bod*" OR CADASIL OR "cognit* impair*" OR FTD OF FTLD OR "cerebrovascular insufficienc*" OR AD OR VCI) ANDTOPIC: ("Animal Assisted" OR "animal facilitated" OR "animal visit" OR "visiting animal" OR CAT OR DOG OR HORSE OR "companion animal*" OR "service animal *") AND TOPIC:(randomly OR randomised OR randomized OR "random allocat*" OR RCT OR CCT OR "double blind*" OR "single blind*" OR "double blind*" OR "single blind*" OR trial)	Dec 2018: 450 Sep 2019: 78
LILACS (BIREME) (Date of most recent search: 5 September 2019)	"Animal Assisted" OR "animal facilitated" OR "animal visit" OR "visiting animal" OR "companion animal$" OR "service animal$" [Words] and alzheimer OR alzheimers OR alzheimer's OR dementia OR demenc$ [Words] and randomly OR randomised OR randomized OR RCT OR "controlled trial" OR "double blind$" OR placebo [Words]	Dec 2018: 0 Sep 2019: 0
ClinicalTrials.gov (www.clinicaltrials.gov) [Date of most recent search: 5 September 2019]	"Animal Assisted" OR "animal facilitated" OR "animal visit" OR "visiting animal" OR CAT OR DOG OR HORSE OR "companion animal*" OR "service animal*" | dementia OR alzheimers OR cognition OR cognitive	Dec 2018: 417 Sep 2019: 16
ICTRP [Date of most recent search: 5 September 2019]	"Animal Assisted" OR "animal facilitated" OR "animal visit" OR "visiting animal" OR "companion animal*" OR "service animal*" | dementia OR alzheimers OR cognition OR cognitive	Dec 2018: 144 Sep 2019: 58
TOTAL before de‐duplication		Dec 2018:2517 Sep 2019:493 TOTAL: 3010
TOTAL after deduplication		Dec 2018: 1879 Sep 2019: 476 TOTAL: 2355
TOTAL after first assessment of titles and abstract by CDCIG information specialists (performed for the first search but not the top‐up search)		Dec 2018:73 Sep 2019: 476 TOTAL: 549