Summary of findings 2. Acellular dermal matrix versus control.
| Acellular dermal matrix for patients undergoing parotidectomy | |||||||
|
Patient or population: patients undergoing parotidectomy
Settings: hospitals
Intervention: acellular dermal matrix Comparison: no graft | |||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Certainty of the evidence (GRADE) | Comments | ||
| Assumed risk | Corresponding risk | ||||||
| Control | Acellular dermal matrix | ||||||
| Incidence rate of Frey's syndrome assessed clinically Follow‐up: > 6 months | 6 out of 15 | 0 out of 15 | RR 0.08 (0.00 to 1.25) | 30 (1 studies) | ⊕⊝⊝⊝ very low1 | There were no events in the acellular dermal matrix group. | |
|
Other complications As measured by clinical methods Follow‐up: > 6 months |
Wound infection | 0 out of 32 | 8 out of 32 | RR 17.00 (1.02 to 282.67) | 64 (1 study) | ⊕⊕⊝⊝ low1 | There were no events in the control group. |
| Seroma/sialoceles | 94 per 1000 | 218 per 1000 (62 to 772) | RR 2.33 (0.66 to 8.23) | 64 (1 study) | ⊕⊕⊝⊝ low1 | — | |
|
Incidence rate of Frey's syndrome assessed by participants Follow‐up: > 6 months |
94 per 1000 |
31 per 1000 (0 to 288) |
RR 0.33 (0.04 to 3.04) | 64 (1 study) | ⊕⊕⊝⊝ low1 | — | |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio | |||||||
| GRADE Working Group grades of evidence High certainty: Further research is very unlikely to change our confidence in the estimate of effect. Moderate certainty: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low certainty: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low certainty: We are very uncertain about the estimate. | |||||||
1Downgraded two levels due to serious imprecision (single study of 64 participants). 2Downgraded two levels due to serious risk of bias.