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. 2019 Oct 3;2019(10):CD012323. doi: 10.1002/14651858.CD012323.pub2

Xue 2010.

Methods Two‐arm, single‐centre, parallel‐group RCT, with 12 to 18 months of follow‐up
Participants Location: China
Setting of recruitment and treatment: the Affiliated Hospital of Medical College Qingdao University
Sample size:
  • Number randomised: 256 (148 in intervention group, 108 in comparison group)

  • Number completed: 256 (148 in intervention group, 108 in comparison group)


Participant (baseline) characteristics:
  • Age: mean 45.6 years (20 to 70)

  • Gender: 140 males and 116 females

  • Types of parotidectomy: superficial parotidectomy

  • Thickness of skin flap: not stated


Inclusion criteria: benign lesions of the parotid gland; aged over 18 years
Exclusion criteria: not stated
Interventions Intervention group (flap group): superficial parotidectomy + acellular dermal matrix
Comparator group (no flap group): superficial parotidectomy
Use of additional interventions: not stated
Outcomes Primary outcome: incidence rate of Frey's syndrome assessed clinically (Minor's starch‐iodine test) (assessed at 1 year after surgery)
 Secondary outcomes: incidence rate of Frey's syndrome assessed by participants (assessed at 1 year after surgery)
Notes We could not make contact with the authors to confirm whether randomisation was strictly performed