| 1 Progression‐free survival |
2 |
|
Hazard Ratio (Random, 95% CI) |
Totals not selected |
| 1.1 First‐line treatment |
1 |
|
Hazard Ratio (Random, 95% CI) |
0.0 [0.0, 0.0] |
| 1.2 Second/third‐line treatment |
1 |
|
Hazard Ratio (Random, 95% CI) |
0.0 [0.0, 0.0] |
| 2 Haematological toxicities |
2 |
|
Risk Ratio (IV, Random, 95% CI) |
Subtotals only |
| 2.1 Anaemia |
2 |
357 |
Risk Ratio (IV, Random, 95% CI) |
1.42 [0.83, 2.44] |
| 2.2 Thrombocytopenia |
2 |
357 |
Risk Ratio (IV, Random, 95% CI) |
2.99 [0.35, 25.64] |
| 2.3 Neutropenia |
1 |
231 |
Risk Ratio (IV, Random, 95% CI) |
0.95 [0.83, 1.07] |
| 2.4 Haemorrhage (non‐CNS) |
1 |
231 |
Risk Ratio (IV, Random, 95% CI) |
0.34 [0.04, 3.19] |
| 3 Gastrointestinal toxicities |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
Totals not selected |
| 3.1 Nausea |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 3.2 Vomiting |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 3.3 Anorexia |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 3.4 Diarrhoea |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 4 Skin toxicities |
2 |
|
Risk Ratio (IV, Random, 95% CI) |
Subtotals only |
| 4.1 Stomatitis |
1 |
126 |
Risk Ratio (IV, Random, 95% CI) |
9.00 [0.49, 163.75] |
| 4.2 Mucositis |
2 |
357 |
Risk Ratio (IV, Random, 95% CI) |
10.42 [1.34, 80.74] |
| 5 Vascular disorders |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
Totals not selected |
| 5.1 Venous thrombosis |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 5.2 Pulmonary embolism |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 6 Metabolic abnormalities |
2 |
|
Risk Ratio (IV, Random, 95% CI) |
Subtotals only |
| 6.1 Hyperglycaemia |
2 |
357 |
Risk Ratio (IV, Random, 95% CI) |
4.49 [0.33, 60.28] |
| 6.2 Hyperlipidaemia |
2 |
357 |
Risk Ratio (IV, Random, 95% CI) |
7.58 [0.94, 60.97] |
| 7 Respiratory toxicity |
2 |
|
Risk Ratio (IV, Random, 95% CI) |
Subtotals only |
| 7.1 Interstitial pneumonitis |
2 |
357 |
Risk Ratio (IV, Random, 95% CI) |
7.36 [0.88, 61.52] |
| 8 Overall survival |
2 |
|
Hazard Ratio (Random, 95% CI) |
Totals not selected |
| 8.1 First‐line treatment |
1 |
|
Hazard Ratio (Random, 95% CI) |
0.0 [0.0, 0.0] |
| 8.2 Second/third‐line treatment |
1 |
|
Hazard Ratio (Random, 95% CI) |
0.0 [0.0, 0.0] |
| 9 Objective response rate |
2 |
|
Risk Ratio (IV, Random, 95% CI) |
Totals not selected |
| 9.1 First‐line treatment |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 9.2 Second/third‐line treatment |
1 |
|
Risk Ratio (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
