Skip to main content
. 2019 Dec 12;2019(12):CD011927. doi: 10.1002/14651858.CD011927.pub2

Chen 2007.

Methods Design: randomised controlled trial, parallel design
Setting: outpatients and hospitalised patients, single centre
Country: Republic of China
Participants Sample size/available for analysis: 70/70
Gender: 30 females/40 males
Age (years, mean and SD): 42.47 (± 14.07) years
Duration of disease (months, mean and SD): 18.51 (± 8.43) months
Inclusion criteria: "cervicogenic headache in accordance with the diagnostic criteria of Sjaastad; and at the same time one of the following conditions: course ≥ 6 months; nearly 3 months without any medication; cervical spine X‐ray inspection shows that the cervical spine has no degenerative changes."
Exclusion criteria: "neurological diagnosis of other types of headache; cervical spine fracture, dislocation or discectomy and severe osteoporosis are not suitable for manipulation or nerve stimulation therapy."
Interventions Group 1: TENS (n = 34)
Group 2: manipulation treatment (n = 36)
Treatment duration: 4 weeks
Follow‐up duration: 6 weeks
Schemes of TENS: two 75 mm × 115 mm electrodes were placed in the upper cervical spine on both sides, symmetrical two‐way square wave output, frequency 100 Hz, pulse width 250 μs, 20 min each time during the course of treatment (10 sessions)
Outcomes
  • Pain (numerical pain scale)

  • Range of motion (in degrees)

Notes Funding sources: not reported
Conflict of interest: not reported
Full text language: Chinese
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "...with cervicogenic headache were randomly allocated to receive manipulation treatment and TENS treatment".
Comment: information provided is not sufficient.
Allocation concealment (selection bias) Unclear risk Quote: "...with cervicogenic headache were randomly allocated to receive manipulation treatment and TENS treatment".
Comment: information provided is not sufficient.
Blinding of participants High risk Comment: different interventions (TENS and manipulation therapy) were compared and blinding was not possible.
Blinding of personnel/providers High risk Comment: due to the nature of the intervention, it was not possible to blind the physician who provided the intervention.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: no available information
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: there were no losses of participants.
ITT analysis Low risk No losses
Selective reporting (reporting bias) Unclear risk Comment: the study protocol was not available.
Group similarity at baseline Low risk Comment: the three groups seem to be similar at baseline.
Cointerventions Low risk No cointerventions
Compliance Unclear risk Comment: compliance with the intervention was not reported.
Timing of outcome assessments Low risk Comment: timing of outcome assessment is identical for all intervention groups and for all primary outcome measures.
Other bias Low risk Comment: no other biases were identified.