Comparison 3. Target of rapamycin inhibitors (TOR‐I) versus calcineurin inhibitors (CNI): outcomes at 5 to 8 years post transplant.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death	2	206	Risk Ratio (M‐H, Random, 95% CI)	1.36 [0.60, 3.08]
2 Total graft loss	2	206	Risk Ratio (M‐H, Random, 95% CI)	0.86 [0.44, 1.68]
3 Graft loss censored for death	2	206	Risk Ratio (M‐H, Random, 95% CI)	0.68 [0.25, 1.81]
4 Malignancies	2	206	Risk Ratio (M‐H, Random, 95% CI)	0.48 [0.20, 1.13]
5 Glomerular filtration rate	2	163	Mean Difference (IV, Random, 95% CI)	13.51 [6.94, 20.08]