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. 2019 Dec 16;2019(12):CD004290. doi: 10.1002/14651858.CD004290.pub3

Comparison 7. Variable doses of target of rapamycin inhibitors (TOR‐I) and calcineurin inhibitors (CNI): primary outcomes.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Death (all causes) 9 1501 Risk Ratio (M‐H, Random, 95% CI) 1.07 [0.64, 1.78]
2 Total graft loss 8 1385 Risk Ratio (M‐H, Random, 95% CI) 1.09 [0.68, 1.75]
3 Graft loss censored for death 8 1385 Risk Ratio (M‐H, Random, 95% CI) 1.09 [0.54, 2.20]
4 All acute rejection 9 1509 Risk Ratio (M‐H, Random, 95% CI) 0.84 [0.67, 1.07]
5 Biopsy‐proven acute rejection 8 1381 Risk Ratio (M‐H, Random, 95% CI) 0.87 [0.67, 1.13]
6 CMV infection 5 865 Risk Ratio (M‐H, Random, 95% CI) 1.42 [0.78, 2.60]
7 Adverse wound outcomes 5   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
7.1 All complications 3 291 Risk Ratio (M‐H, Random, 95% CI) 0.95 [0.53, 1.71]
7.2 Lymphocoele 3 702 Risk Ratio (M‐H, Random, 95% CI) 0.86 [0.45, 1.63]
8 All malignancies 7 1163 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.36, 3.04]
9 Number needing to change treatment 5 734 Risk Ratio (M‐H, Random, 95% CI) 1.18 [0.58, 2.42]