Comparison 8. Variable doses of target of rapamycin inhibitors (TOR‐I) and calcineurin inhibitors (CNI): secondary outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 New‐onset diabetes mellitus	8		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Tacrolimus	5	580	Risk Ratio (M‐H, Random, 95% CI)	1.79 [0.99, 3.23]
1.2 Cyclosporin	3	606	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.27, 1.20]
2 Lymphoma/PTLD	7	1298	Risk Ratio (M‐H, Random, 95% CI)	0.68 [0.15, 3.07]
3 Adverse cosmetic outcomes	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Tremor	3	537	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.34, 2.45]
3.2 Gingival hyperplasia ‐ cyclosporin	1	285	Risk Ratio (M‐H, Random, 95% CI)	2.98 [0.12, 72.52]
3.3 Hirsutism ‐ cyclosporin	1	186	Risk Ratio (M‐H, Random, 95% CI)	20.56 [1.22, 345.79]
4 Glomerular filtration rate	7	1305	Mean Difference (IV, Random, 95% CI)	‐5.96 [‐9.54, ‐2.38]
5 Serum creatinine	9	1368	Mean Difference (IV, Random, 95% CI)	1.53 [‐8.82, 11.89]
6 Elevated lipid levels	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
6.1 Hypercholesterolaemia	4	734	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.75, 1.22]
6.2 Hypertriglyceridaemia	4	734	Risk Ratio (M‐H, Random, 95% CI)	0.85 [0.73, 1.01]
7 Lipid outcomes	4		Mean Difference (IV, Random, 95% CI)	Subtotals only
7.1 Total cholesterol	4	709	Mean Difference (IV, Random, 95% CI)	0.24 [‐0.98, 1.45]
7.2 Total triglycerides	3	413	Mean Difference (IV, Random, 95% CI)	‐0.13 [‐0.55, 0.29]
8 Abnormal haematologic values	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
8.1 Anaemia	6	1074	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.80, 1.08]
8.2 Leucopenia	5	1012	Risk Ratio (M‐H, Random, 95% CI)	0.99 [0.70, 1.40]
8.3 Thrombocytopenia	5	888	Risk Ratio (M‐H, Random, 95% CI)	0.67 [0.43, 1.07]
9 Haematological outcomes	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
9.1 White cell count [per mm3]	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
9.2 Haemoglobin [g/dL]	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
9.3 Platelet count [per mm2]	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]