Pascual 2010.

Methods	Design: open‐label RCT Duration: not reported Mean follow‐up: 6 months (3 withdrawn group 1; 5 in group 2)
Participants	Setting: multicentre, (5 centres) Country: Spain Patients suffering from ESKD who were candidates for primary kidney transplant or re‐transplant (except if the original graft was lost due to immunologic causes within the previous 12 months) from an ABO‐compatible donor Number (group 1/group 2): 35 (15/20) Mean age ± SD (years): group 1 (44 ± 11.2); group 2 (46.2 ± 10.2) Sex (M/F): group 1 (10/5); group 2 (14/6) Exclusions: DGF; graft from a heart‐arrest donor or from a donor’s kidney with cold ischaemia time > 30 hours; thrombocytopenia; leukopenia; significant liver disease or liver cirrhosis
Interventions	Treatment group 1 Low‐dose EVL: 0.75 mg/twice/d unchanged to day 42; then levels of 3 to 8 ng/mL sTAC: 0.075 mg/kg twice/d for levels 10 to 25 ng/mL to 14 days; 5 to 10 after 14 days Treatment group 2 High‐dose EVL: 1.5 mg twice/d unchanged to day 42; then levels of 3 to 8 ng/mL sTAC: 0.075 mg/kg twice/d for levels 10 to 25 ng/mL to 14 days; 5 to 10 after 14 days Co‐interventions MP: 500 mg day 0, 125 mg day 1 Prednisone 20 mg day 2, tapered to a maintenance dose of 5 mg from day 42 to study end
Outcomes	PK1 profiles of EVR and TAC Acute rejection Graft loss
Notes	Comparison: EVL low dose versus EVL high dose
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Said to be randomised; insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label study
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Primary outcome lab based and unlikely to influence blinding
Incomplete outcome data (attrition bias) All outcomes	High risk	8/35 withdrawn (22%)
Selective reporting (reporting bias)	Low risk	All pre‐specified outcomes mentioned
Other bias	Unclear risk	Insufficient information to permit judgement