for the main comparison.
| Early post‐operative MRI compared with no early post‐operative MRI for glioblastoma | |||||
|
Patient or population: adults with glioblastoma Settings: tertiary care Intervention: early post‐operative MRI (within 48 hours of tumour resection) Comparison: no early post‐operative MRI | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| No early MRI | Early MRI | ||||
| Overall survival (deaths at 1 year) | 554 per 1000 | 476 per 1000 (338 to 670) | (RR 0.86, 95% CI 0.61 to 1.21) | 125 (1) | ⊕⊕⊝⊝ very low1 |
| Overall survival (deaths at 2 years) | 804 per 1000 | 852 per 1000 (732 to 1000) | (RR 1.06, 95% CI 0.91 to 1.25) | 125 (1) | ⊕⊕⊝⊝ very low1 |
| Progression free survival | no evidence | ||||
| Anxiety | no evidence | ||||
| Quality of life | no evidence | ||||
| *The basis for the assumed risk is the risk in the control group of the included study. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio | |||||
| GRADE Working Group grades of evidence High certainty: Further research is very unlikely to change our confidence in the estimate of effect. Moderate certainty: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low certainty: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low certainty: We are very uncertain about the estimate. | |||||
1Downgraded for risk of bias, as the patients in this study received the interventions based on surgeons' preferences and discretion