4.

Proportion of participants with detectable hepatitis B virus DNA (HBV‐DNA): Trial Sequential Analysis (risk ratio (RR) random‐effects model) including randomised clinical trials comparing Xiao Chai Hu Tang formula versus no intervention for people with chronic hepatitis B. The pair‐wise meta‐analysis included three trials with 222 participants and found an RR of 0.62 (95% CI 0.17 to 2.80). The Trial Sequential Analysis was made with event proportion in the control group 47.1%, relative risk reduction 15%, alpha 5.0%, power 90%, and model‐based diversity 0%. The Trial Sequential Analysis‐adjusted confidence interval was 0.17 to 2.80.