| 1 Change in FEV1 (% predicted) |
4 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.1 8 days to 1 month |
1 |
10 |
Mean Difference (IV, Fixed, 95% CI) |
0.60 [‐6.33, 7.53] |
| 1.2 2 to 3 months |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.5 [‐3.68, 2.68] |
| 1.3 7 to 12 months |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
8.26 [0.76, 15.76] |
| 1.4 2 years |
1 |
66 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.65 [‐3.25, 1.95] |
| 2 Change in FVC (% predicted) |
5 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 2.1 Single treatment |
1 |
16 |
Mean Difference (IV, Fixed, 95% CI) |
1.90 [‐4.96, 8.76] |
| 2.2 8 days to 1 month |
2 |
26 |
Mean Difference (IV, Fixed, 95% CI) |
‐4.18 [‐12.92, 4.56] |
| 2.3 > 1 to 3 months |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
2.09 [‐5.46, 9.64] |
| 2.4 > 6 to 12 months |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
8.74 [1.44, 16.04] |
| 2.5 > 1 to 2 years |
1 |
66 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.57 [‐4.33, 1.19] |
| 3 Change in FEF25‐75 (% predicted) |
3 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3.1 8 days to 1 month |
1 |
10 |
Mean Difference (IV, Fixed, 95% CI) |
‐6.2 [‐14.41, 2.01] |
| 3.2 > 1 to 3 months |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.08 [‐7.87, 1.71] |
| 3.3 > 6 to 12 months |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
3.56 [‐6.18, 13.30] |
| 4 TLC |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 4.1 > 1 to 3 months |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.38 [‐13.67, 6.91] |
| 5 Radiological imaging: increased bronchial markings |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 5.1 > 6 to 12 months |
1 |
26 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.88 [0.69, 1.12] |
| 6 Radiological imaging: change in Brasfield score |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 6.1 > 6 to 12 months |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐1.20, 1.20] |
| 7 Adverse events |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 7.1 Gastrointestinal reflux |
1 |
26 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.25 [0.43, 3.63] |
| 7.2 Gastrointestinal reflux leading to withdrawal from the study |
1 |
26 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.14 [0.01, 2.52] |
