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. 2019 Oct 7;2019(10):CD004052. doi: 10.1002/14651858.CD004052.pub2

16. Adverse events ‐ valproate vs lithium (children and adolescents).

Adverse effect Odds ratio; 95% CI; heterogeneity; N of studies, N of participants P value
Abdominal pain OR 0.58, 95% CI 0.31 to 1.07; 1 study, 190 participants P = 0.08
Appetite increase OR 0.73, 95% CI 0.37 to 1.43; 1 study, 190 participants P = 0.36
Diarrhoea OR 1.84, 95% CI 0.78 to 4.37; 1 study, 190 participants P = 0.17
Dry mouth/excessive thirst OR 0.34, 95% CI 0.17 to 0.65; 1 study, 190 participants P = 0.001
Nasal congestion OR 1.36, 95% CI 0.70 to 2.64; 1 study, 190 participants P = 0.36
Enuresis OR 1.00, 95% CI 0.49 to 2.04; 1 study, 190 participants P = 1.00
Fever OR 1.68, 95% CI 0.54 to 5.22; 1 study, 190 participants P = 0.37
Frequent urination OR 0.45, 95% CI 0.22 to 0.93; 1 study, 190 participants P = 0.03
Nausea OR 0.60, 95% CI 0.32 to 1.13; 1 study, 190 participants P = 0.11
Rash OR 2.54, 95% CI 0.87 to 7.43; 1 study, 190 participants P = 0.09
Sedation OR 1.59, 95% CI 0.84 to 3.00; 1 study, 190 participants P = 0.15
Vomiting OR 0.49, 95% CI 0.22 to 1.11; 1 study, 190 participants P = 0.09
Weight gain OR 1.35, 95% CI 0.73 to 2.49; 1 study, 190 participants P = 0.33
Weight loss OR 1.19, 95% CI 0.63 to 2.26; 1 study, 190 participants P = 0.60