| Adverse effect |
Odds ratio; 95% CI; heterogeneity; N of studies, N of participants |
P value |
| Abnormal hepatic function |
Not estimable |
N/A |
| Agitation |
OR 0.99, 95% CI 0.45 to 2.17; 1 study, 251 participants |
P = 0.98 |
| Alopecia (hair loss) |
OR 7.56, 95% CI 0.38 to 151.28; 1 study, 80 participants |
P = 0.19 |
| Asthena |
OR 0.82, 95% CI 0.41 to 1.65; 1 study, 251 participants |
P = 0.58 |
| Constipation |
OR 0.46, 95% CI 0.11 to 1.89; I2 = 64%; 2 studies, 331 participants |
P = 0.28 |
| Dizziness |
OR 0.32, 95% CI 0.03 to 3.11; I2 = 61%; 2 studies, 331 participants |
P = 0.33 |
| Diarrhea |
OR 2.28, 95% CI 0.95 to 5.50; 1 study, 251 participants |
P = 0.07 |
| Dyspepsia |
OR 0.74, 95% CI 0.35 to 1.57; studies = 1; participants = 251 |
p = 0.44 |
| Headache |
OR 1.44, 95% CI 0.68 to 3.07; I2 = 56%; 2 studies, 667 participants |
P = 0.34 |
| Increased appetite |
OR 0.45, 95% CI 0.08 to 2.40; I2 = 80%; 2 studies, 667 participants |
P = 0.35 |
| Insomnia |
OR 6.17, 95% CI 1.35 to 28.17; 1 study, 416 participants |
P = 0.02 |
| Nausea |
OR 4.12, 95% CI 2.22 to 7.62; I2 = 0%; 3 studies, 747 participants |
P < 0.001 |
| Neck rigidity |
OR 0.21, 95% CI 0.04 to 0.98; 1 study, 251 participants |
P = 0.05 |
| Nervousness |
OR 1.72, 95% CI 0.82 to 3.62; 1 study, 251 participants |
P = 0.15 |
| Oedema |
OR 0.05, 95% CI 0.00 to 0.81; 1 study, 120 participants |
P = 0.04 |
| Pain |
OR 1.06, 95% CI 0.52 to 2.16; 1 study, 251 participants |
P = 0.88 |
| Rhinitis |
OR 0.53, 95% CI 0.16 to 1.72; 1 study, 120 participants |
P = 0.29 |
| Sedation |
OR 0.50, 95% CI 0.28 to 0.91; I2 = 0%; 2 studies, 536 participants |
P = 0.02 |
| Sleep disorder |
OR 0.13, 95% CI 0.02 to 1.11; 1 study, 251 participants |
P = 0.06 |
| Somnolence |
OR 0.36, 95% CI 0.23 to 0.57; I2 = 0%; 3 studies, 747 participants |
P < 0.001 |
| Speech disorder |
OR 0.09, 95% CI 0.02 to 0.50; I2 = 0%; 2 studies, 371 participants |
P = 0.006 |
| Tongue edema |
OR 0.07, 95% CI 0.00 to 1.30; 1 study, 251 participants |
P = 0.08 |
| Tremor |
OR 0.28, 95% CI 0.09 to 0.82; I2 = 0%; 2 studies, 331 participants |
P = 0.02 |
| Vomiting |
OR 1.92, 95% CI 0.85 to 4.34; 1 study, 251 participants |
P = 0.12 |
| Weight gain |
OR 0.44, 95% CI 0.28 to 0.70; I2 = 0%; 4 studies, 867 participants |
P < 0.001 |
| Xerostomia (dry mouth) |
OR 0.25, 95% CI 0.11 to 0.57; I2 = 44%; 3 studies, 747 participants |
P = 0.001 |
