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. 2019 Oct 7;2019(10):CD004052. doi: 10.1002/14651858.CD004052.pub2

22. Adverse events ‐ valproate vs risperidone (children and adolescents).

Adverse effect Odds ratio; 95% CI; heterogeneity; N of studies, N of participants P value
Abdominal pain OR 14.49, 95% CI 0.54 to 389.63; I2 = 57%; 2 studies, 228 participants P = 0.11
Appetite increase OR 0.08, 95% CI 0.04 to 0.16; 1 study, 189 participants P < 0.001
Dry mouth/excessive thirst OR 0.44, 95% CI 0.23 to 0.85; 1 study, 189 participants P = 0.01
Enuresis OR 2.74, 95% CI 0.01 to 829.22; I2 = 87%; 2 studies, 228 participants P = 0.73
Excitement OR 4.74, 95% CI 0.21 to 105.54; 1 study, 39 participants P = 0.33
Fever OR 0.88, 95% CI 0.33 to 2.32; 1 study, 189 participants P = 0.79
Frequent urination OR 2.25, 95% CI 0.83 to 6.14; 1 study, 189 participants P = 0.11
Headache OR 0.06, 95% CI 0.00 to 1.12; 1 study, 39 participants P = 0.06
Initial insomnia OR 0.27, 95% CI 0.01 to 7.08; 1 study, 39 participants P = 0.43
Irritability OR 0.15, 95% CI 0.01 to 3.42; 1 study, 39 participants P = 0.24
Nasal congesion OR 1.38, 95% CI 0.72 to 2.64; I2 = 0%; 2 studies, 228 participants P = 0.33
Nausea OR 1.47, 95% CI 0.71 to 3.04; 1 study, 189 participants P = 0.29
Outburst of anger OR 2.00, 95% CI 0.42 to 9.52; 1 study, 39 participants P = 0.38
Rash OR 2.07, 95% CI 0.75 to 5.69; 1 study, 189 participants P = 0.16
Sadness OR 0.58, 95% CI 0.11 to 3.04; 1 study, 39 participants P = 0.52
Sedation OR 0.50, 95% CI 0.28 to 0.91; 1 study, 189 participants P = 0.02
Vomiting OR 1.45, 95% CI 0.54 to 3.91; 1 study, 189 participants P = 0.47
Weight gain OR 0.12, 95% CI 0.04 to 0.34; 1 study, 189 participants P < 0.001
Weight loss OR 3.63, 95% CI 1.61 to 8.19; 1 study, 189 participants P = 0.002