Comparison 3. Valproate vs endoxifen.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Response rate (adults)	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 at 3 weeks	1	84	Odds Ratio (M‐H, Random, 95% CI)	2.19 [0.83, 5.78]
2 Number with any adverse event (adults)	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Adults	1	84	Odds Ratio (M‐H, Random, 95% CI)	1.88 [0.73, 4.86]
3 Individual adverse events (adults)	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Headache	1	84	Odds Ratio (M‐H, Random, 95% CI)	1.15 [0.26, 5.21]
3.2 Insomnia	1	84	Odds Ratio (M‐H, Random, 95% CI)	3.61 [0.80, 16.36]
3.3 Nausea	1	84	Odds Ratio (M‐H, Random, 95% CI)	5.52 [1.00, 30.50]