Comparison 8. Valproate vs oxcarbazepine.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Number with any adverse event (adults)	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Adults	1	60	Odds Ratio (M‐H, Random, 95% CI)	4.67 [1.57, 13.87]
2 Individual adverse events (adults)	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Alopecia	1	60	Odds Ratio (M‐H, Random, 95% CI)	3.10 [0.12, 79.23]
2.2 Constipation	1	60	Odds Ratio (M‐H, Random, 95% CI)	7.76 [0.38, 157.14]
2.3 Diarrhoea	1	60	Odds Ratio (M‐H, Random, 95% CI)	5.35 [0.25, 116.31]
2.4 Dizziness	1	60	Odds Ratio (M‐H, Random, 95% CI)	2.74 [0.63, 11.82]
2.5 Dry mouth	1	60	Odds Ratio (M‐H, Random, 95% CI)	2.07 [0.18, 24.15]
2.6 Dyspepsia	1	60	Odds Ratio (M‐H, Random, 95% CI)	1.0 [0.19, 5.40]
2.7 Headache	1	60	Odds Ratio (M‐H, Random, 95% CI)	2.25 [0.51, 9.99]
2.8 Increased appetite	1	60	Odds Ratio (M‐H, Random, 95% CI)	7.76 [0.38, 157.14]
2.9 Nausea	1	60	Odds Ratio (M‐H, Random, 95% CI)	1.52 [0.42, 5.47]
2.10 Pain in abdomen	1	60	Odds Ratio (M‐H, Random, 95% CI)	13.16 [0.69, 249.48]
2.11 Rash	1	60	Odds Ratio (M‐H, Random, 95% CI)	3.10 [0.12, 79.23]
2.12 Sedation	1	60	Odds Ratio (M‐H, Random, 95% CI)	1.8 [0.39, 8.32]
2.13 Thrombocytopenia	1	60	Odds Ratio (M‐H, Random, 95% CI)	3.10 [0.12, 79.23]
2.14 Vomiting	1	60	Odds Ratio (M‐H, Random, 95% CI)	1.63 [0.41, 6.47]
2.15 Weight gain	1	60	Odds Ratio (M‐H, Random, 95% CI)	10.36 [0.53, 201.45]
3 Remission rate (adults)	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 at 12 weeks	1	60	Odds Ratio (M‐H, Random, 95% CI)	2.25 [0.51, 9.99]
4 Change in symptom severity (adults)	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 at 3 days	1	60	Mean Difference (IV, Random, 95% CI)	1.60 [‐1.24, 4.44]
4.2 at 3 weeks	1	60	Mean Difference (IV, Random, 95% CI)	0.73 [‐2.17, 3.63]
4.3 at 8 weeks	1	60	Mean Difference (IV, Random, 95% CI)	‐0.40 [‐2.60, 1.80]