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. 2019 Nov 13;2019(11):CD011116. doi: 10.1002/14651858.CD011116.pub3

Summary of findings 2. Acupressure with thumb, device or sea band compared to sham acupressure with or without sedation for gagging in patients undergoing dental treatment.

Acupressure with thumb, device or sea band compared to sham acupressure with or without sedation for gagging in patients undergoing dental treatment
Patient or population: patients undergoing dental treatment
Setting: university hospital
Intervention: acupressure at P6 point with thumb, device or sea band with or without sedation
Comparison: sham acupressure with or without sedation
Outcomes Anticipated absolute effects* (95% CI) Relative effect(95% CI) Number of participants(studies) Certainty of the evidence(GRADE) Comments
Risk with sham acupressure Risk with acupressure
Presence or absence of gagging None of the trials comparing acupressure with thumb, device or sea band to sham acupressure with or without sedation reported this outcome
Adverse effects None of the trials comparing acupressure with thumb, device or sea band to sham acupressure with or without sedation reported adverse effects
Acupressure with thumb
Completion of dental procedure Study population RR 0.85
(0.50 to 1.46)
30
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
692 per 1000 588 per 1000
(346 to 1000)
Reduction in gagging
(patient‐reported)
Study population RR 0.92
(0.60 to 1.41)
30
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
769 per 1000 708 per 1000
(462 to 1000)
Acupressure with device
Completion of dental procedure Study population RR 2.63
(1.33 to 5.18) 34
(1 RCT)a ⊕⊝⊝⊝
VERY LOWb,c,d  
333 per 1000 877 per 1000
(443 to 1000)
Reduction in gagging
(patient‐reported)
Study population RR 3.94
(1.63 to 9.53) 34
(1 RCT)a ⊕⊝⊝⊝
VERY LOWb,c,d  
222 per 1000 876 per 1000
(362 to 1000)
Acupressure with sea band
Completion of dental procedure Study population RR 1.80
(0.63 to 5.16) 19
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
333 per 1000 600 per 1000
(210 to 1000)
Reduction in gagging
(patient‐reported)
Study population RR 2.70
(0.72 to 10.14) 19
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
222 per 1000 600 per 1000
(160 to 1000)
Acupressure with thumb with sedation
Completion of dental procedure Study population RR 0.96
(0.84 to 1.10) 39
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
1000 per 1000 960 per 1000
(840 to 1000)
Reduction in gagging
(patient‐reported)
Study population RR 1.06
(0.92 to 1.23) 39
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
944 per 1000 1000 per 1000
(869 to 1000)
Acupressure with device with sedation
Completion of dental procedure Study population RR 1.16
(0.90 to 1.48) 27
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
857 per 1000 994 per 1000
(771 to 1000)
Reduction in gagging
(patient‐reported)
Study population RR 1.26
(0.93 to 1.69) 27
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
786 per 1000 990 per 1000
(731 to 1000)
Acupressure with sea band with sedation
Completion of dental procedure Study population RR 0.88
(0.67 to 1.17) 21
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
1000 per 1000 880 per 1000
(670 to 1000)
Reduction in gagging
(patient‐reported)
Study population RR 0.88
(0.67 to 1.17) 21
(1 RCT)a
⊕⊝⊝⊝
VERY LOWb,c,d  
1000 per 1000 880 per 1000
(670 to 1000)
*The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)

CI: confidence interval; P6: point located 3‐finger breadths below the wrist on the inner forearm in between the 2 tendons; RR: risk ratio; RCT: randomised controlled trial
GRADE Working Group grades of evidenceHigh certainty: we are very confident that the true effect lies close to that of the estimate of the effect
Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect
Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect

aLu 2000.
bDowngraded 1 level for unclear risk of bias.
cDowngraded 1 level for indirectness: single trial done only in adults.
dDowngraded 1 level, imprecision apparent from width of confidence interval (due to small sample size).