Comparison 1. Progesterone versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Seizure freedom	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 All seizures	1	124	Risk Ratio (M‐H, Fixed, 95% CI)	4.03 [0.21, 76.21]
1.2 Most severe seizure type	1	124	Risk Ratio (M‐H, Fixed, 95% CI)	2.09 [0.61, 7.10]
2 Responder rate (50% reduction in seizure frequency)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 All seizures	1	124	Risk Ratio (M‐H, Fixed, 95% CI)	1.14 [0.56, 2.32]
2.2 Most severe seizure type	1	124	Risk Ratio (M‐H, Fixed, 95% CI)	1.24 [0.67, 2.29]
2.3 Secondarily generalised motor seizures	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	1.34 [0.57, 3.13]
2.4 Complex partial seizures	1	119	Risk Ratio (M‐H, Fixed, 95% CI)	1.27 [0.60, 2.68]
2.5 Simple partial seizures	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.50, 2.01]
3 Seizure frequency	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 In the 3 months before the study	1	36	Mean Difference (IV, Fixed, 95% CI)	‐1.40 [‐4.39, 1.59]
3.2 In the 3 months after the study	1	36	Mean Difference (IV, Fixed, 95% CI)	‐4.5 [‐6.55, ‐2.45]
4 Number of withdrawals from the study	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Withdrawals for any reason	2	168	Risk Ratio (M‐H, Fixed, 95% CI)	1.56 [0.81, 3.00]
4.2 Withdrawals due to adverse events	2	168	Risk Ratio (M‐H, Fixed, 95% CI)	2.91 [0.53, 16.17]
5 Any adverse events reported	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6 Adverse events reported in > 5% of participants	1		Risk Ratio (M‐H, Fixed, 99% CI)	Subtotals only
6.1 Diarrhoea	1	130	Risk Ratio (M‐H, Fixed, 99% CI)	0.53 [0.09, 3.07]
6.2 Dyspepsia	1	130	Risk Ratio (M‐H, Fixed, 99% CI)	0.53 [0.04, 6.66]
6.3 Nausea	1	130	Risk Ratio (M‐H, Fixed, 99% CI)	0.08 [0.00, 3.65]
6.4 Vomiting	1	130	Risk Ratio (M‐H, Fixed, 99% CI)	0.53 [0.04, 6.66]
6.5 Fatigue	1	130	Risk Ratio (M‐H, Fixed, 99% CI)	1.48 [0.42, 5.20]
6.6 Nasopharyngitis	1	130	Risk Ratio (M‐H, Fixed, 99% CI)	0.18 [0.00, 11.65]
6.7 Dizziness	1	130	Risk Ratio (M‐H, Fixed, 99% CI)	0.26 [0.05, 1.54]
6.8 Headache	1	130	Risk Ratio (M‐H, Fixed, 99% CI)	0.79 [0.08, 7.94]
6.9 Depression	1	130	Risk Ratio (M‐H, Fixed, 99% CI)	2.12 [0.12, 36.26]