Comparison 1. SSRI versus control at end of treatment, by SSRI.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Disability (primary analysis)	2	2829	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.01 [‐0.09, 0.06]
1.1 Fluoxetine	2	2829	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.01 [‐0.09, 0.06]
2 Independent on modified Rankin score (mRS 0 to 2) (primary analysis)	3	3249	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.91, 1.09]
3 Neurological deficit score	2	142	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐0.63, 0.04]
3.1 Fluoxetine	2	142	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐0.63, 0.04]
4 Depression (continuous data)	2	2861	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.19, ‐0.04]
4.1 Fluoxetine	2	2861	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.19, ‐0.04]
5 Depression (dichotomous data)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5.1 Fluoxetine	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Death	3	3254	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.79, 1.25]
6.1 Fluoxetine	3	3254	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.79, 1.25]
7 Seizures	3	3275	Risk Ratio (M‐H, Fixed, 95% CI)	1.47 [0.99, 2.18]
7.1 Fluoxetine	3	3275	Risk Ratio (M‐H, Fixed, 95% CI)	1.47 [0.99, 2.18]
8 Gastrointestinal side effects	2	148	Risk Ratio (M‐H, Fixed, 95% CI)	2.19 [1.00, 4.76]
8.1 Fluoxetine	2	148	Risk Ratio (M‐H, Fixed, 95% CI)	2.19 [1.00, 4.76]
9 Bleeding	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9.1 Fluoxetine	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10 Leaving the trial before the end of scheduled follow‐up	3	3277	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.48, 2.10]
10.1 Fluoxetine	3	3277	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.48, 2.10]
11 Motor deficits	3	2936	Std. Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.05, 0.09]
11.1 Fluoxetine	3	2936	Std. Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.05, 0.09]
12 Disability (sensitivity analyses all studies regardless of RoB)	26	5334	Std. Mean Difference (IV, Fixed, 95% CI)	0.23 [0.18, 0.29]
12.1 Fluoxetine	15	3919	Std. Mean Difference (IV, Fixed, 95% CI)	0.14 [0.08, 0.20]
12.2 Sertraline	1	130	Std. Mean Difference (IV, Fixed, 95% CI)	1.38 [0.99, 1.76]
12.3 Paroxetine	5	293	Std. Mean Difference (IV, Fixed, 95% CI)	1.29 [1.03, 1.55]
12.4 Citalopram	5	992	Std. Mean Difference (IV, Fixed, 95% CI)	0.24 [0.11, 0.37]
13 Independent on modified Rankin score (mRS 0 to 2) (sensitivity analysis)	5	4002	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.91, 1.03]
13.1 Fluoxetine	3	3249	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.91, 1.09]
13.2 Sertraline	1	111	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.97, 1.04]
13.3 Citalopram	1	642	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.82, 0.98]