Hu 2002.
Methods | Parallel design Aim: to study effect of antidepressants on depressive symptoms and nervous function |
|
Participants | Country: China Setting: inpatient Stroke criteria: all pathological stroke types, clinical diagnosis plus confirmation by imaging (though unclear whether a relevant lesion had to be visible), onset of stroke 0.5 to 2 months, no obvious aphasia Depression: according to CCMD‐II‐R Treatment: 42 people, mean age 61.4 ± 3.6 years, 32 men Control: 30 people, mean age 60 ± 4.8 years, 23 men |
|
Interventions | Treatment: fluoxetine 20 mg daily Control: no other antidepressant Duration of treatment: 8 weeks Duration of follow‐up (end of treatment to study end): 0 |
|
Outcomes | HAMD MESSS However, these data were not usable, as they were reported as proportions above or below "decrement levels" Reported side effects but unclear how this was done None left the trial early |
|
Funding source | Source of funding not stated | |
Notes | − | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomisation method not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | High risk | No placebo |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No dropouts |
Selective reporting (reporting bias) | Unclear risk | No protocol |
Other bias | Unclear risk | Balanced baseline, no other obvious risks |