Liu 2006.
Methods | Parallel design Aim: to study effect of citalopram on post‐stroke depression and neurological functional rehabilitation |
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Participants | Country: China Setting: inpatient Stroke criteria: stroke during "recovery phase" at 6 to 9 months, NIHSS score ≥ 13, HAMD score ≥ 17 60 people randomised, of whom 38 were men, mean age 60.7 ± 8.6 years. Demographics for treatment and control groups were not provided Treatment: 30 people, age and gender not stated Control: 30 people, age and gender not stated Exclusion criteria: previous psychiatric disorder, dementia, aphasia, consciousness disturbance |
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Interventions | Treatment: citalopram 20 mg daily plus routine stroke care Control: routine stroke care Duration of treatment: 6 weeks Duration of follow‐up (treatment end to study end): 0 |
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Outcomes | HAMD NIHSS BI Death |
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Funding source | Source of funding not stated | |
Notes | AEs not reported | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | High risk | No placebo |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not stated |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No dropouts |
Selective reporting (reporting bias) | Unclear risk | No protocol |
Other bias | Unclear risk | Baseline balance reported by authors |