Wen 2006.

Methods	Parallel trial Aim: to explore effects of prophylactic antidepression therapy on nerve functional rehabilitation after stroke Analysis: according to treatment group
Participants	Country: China Setting: inpatient Stroke criteria: acute stroke of all pathological subtypes, clinical diagnosis plus confirmation by imaging (although not clear whether a stroke lesion had to be present) Treatment: 42 people, mean age 56.8 years, men 19 Control: 42 people, mean age 57.2 years, men 16 Excluded those with primary psychiatric impairment and premorbid mood disorders, pre‐existing neurological disease causing confusion, severe systematic diseases and pulmonary, hepatic and renal failure
Interventions	Treatment: fluoxetine 20 mg daily plus routine stroke care Control: routine stroke care Duration of treatment: 8 weeks Duration of follow‐up (end of treatment to end of study): 0
Outcomes	HAMD MESSS AEs (method of obtaining data not stated) Death
Funding source	Source of funding not stated
Notes	−
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	High risk	No placebo
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	Analysed according to treatment group, no dropouts
Selective reporting (reporting bias)	Unclear risk	No protocol
Other bias	Unclear risk	Balanced baseline