Summary of findings 7. Conscious sedation and analgesia (CSA) + paracervical block (PCB) versus PCB.
| Conscious sedation and analgesia (CSA) plus paracervical block (PCB) compared with PCB only for women undergoing oocyte retrieval for assisted reproduction | ||||||
| Patient or population: women undergoing oocyte retrieval for assisted reproduction Setting: assisted reproduction clinic Intervention: CSA + PCB Comparison: PCB only | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with PCB only |
Risk with CSA + PCB (95% CI) |
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| Intraoperative pain | No studies reported this outcome. | Not estimable | ‐ | ‐ | ‐ | |
| Postoperative pain | No studies reported this outcome. | Not estimable | ‐ | ‐ | ‐ | |
| Pregnancy | 253 per 1000 | 240 per 1000 (130 to 399) |
OR 0.93 (0.44 to 1.96) |
150 (1 RCT) | ⊕⊕⊝⊝ LOWa | |
| Patient satisfaction | 800 per 1000 | 867 per 1000 | OR 1.63 (0.68 to 3.89) |
150 (1 RCT) | ⊕⊕⊝⊝ LOWa | |
| Side effects (postoperative vomiting and/or vomiting) | No studies reported this outcome | Not estimable | ‐ | ‐ | ||
| Postoperative complications | No studies reported this outcome | Not estimable | ‐ | ‐ | ||
| *The risk in the intervention group (and its 95% confidence interval) is based on the risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio; RCT: randomised controlled trial. | ||||||
| GRADE Working Group grades of evidence. High quality: We are very confident that the true effect lies close to that of the estimate of the effect. Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect. | ||||||
aDowngraded two levels for very serious imprecision: low event rates and wide confidence intervals compatible with benefit in either group or no effect.