Ben‐Shlomo 1999.

Methods	Randomisation: random numbers Allocation concealment: sealed in consecutive envelopes Blinding of participants/investigators: no Blinding of assessors: no No. randomised: 50 No. analysed: 50 Intention‐to‐treat analysis: yes Power and sample calculations not described Duration of trial: not stated
Participants	Women scheduled for oocyte retrieval Mean age: 34 years; cause of infertility not reported Similar baseline characteristics of age, height, and weight
Interventions	Control: conscious sedation and analgesia with IV midazolam 0.06 mg followed after 2 minutes by ketamine 0.75 mg/kg (N = 25) Intervention: general anaesthesia with IV fentanyl 0.017 mg/kg followed after 2 minutes by IV propofol 2.5 mg/kg (N = 25) No premedication in either group
Outcomes	Primary: postoperative pain (Likert scale 0 to 3; 0 = none; 3 = severe) Secondary: clinical pregnancy rate, fertilisation rate, satisfaction (Likert scale 0 to 3) Other outcomes reported: no. of oocytes retrieved, cleavage rate, arousability, response to painful stimuli
Notes	Israel Single centre HaEmek Mecical Centre Funding: not stated Definition of pregnancy not documented
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random numbers
Allocation concealment (selection bias)	Low risk	Adequate: sealed envelopes
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Blinding not possible because of the nature of the interventions Blinding of assessors not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	No apparent dropout
Selective reporting (reporting bias)	Low risk	All pre‐stated outcomes reported
Other bias	Unclear risk	Comparable baseline characteristics of age, height, and weight but not cause of infertility