Hoang 2016.
| Methods | Single‐blinded block randomised controlled trial. Allocation by computer‐generated random number schedule | |
| Participants | n=50 Randomised: E = 28, C = 22 Analysed: E = 23, C = 21 No differences at baseline between groups on primary (CSRT & SST) & secondary (CSRT decision & movement time, postural sway, TUG, 10MWT, 6MWT, TMT, SDMT, 9‐HPT, MSFC & number of falls) measures |
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| Interventions | E: 30 minutes, twice per week for 12 weeks at home, of 2 interactive exergames requiring stepping in multiple directions to cues C: no intervention, continued their normal physical activity |
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| Outcomes | Number of falls per group, mobility, dual task mobility, cognition, MS function, stepping reaction time | |
| Notes | E: Exercise, C: Control, CSRT: Choice Stepping Reaction Time, SST: Stroop Stepping Test, TUG: Timed Up and Go, 10MWT: 10 meter walk test, 6MWT: 6 minute walk test, TMT: trail making test, SDMT” symbol digit modalities test, 9‐HPT: 9 hole peg test, MSFC: multiple sclerosis functional composite | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | “Computer generated random number schedule” |
| Allocation concealment (selection bias) | Unclear risk | Insufficient information available to permit a judgement of ‘low risk’ or ‘high risk’ |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Insufficient information available to permit a judgement of ‘low risk’ or ‘high risk’ |
| Blinding of outcome assessment (detection bias) All outcomes | Low risk | “Reassessments were conducted by a physiotherapist who was blind to group allocation”… |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Balanced across groups and reasons for missing data unlikely to be related to outcome |
| Selective reporting (reporting bias) | High risk | Trial registration number ACTRN12612001139864.Additional outcomes presented in the paper to those presented in the protocol including MSFC, TUG, TMT and SDMT |
| Other bias | Low risk | Sample size calculated and required number of participants recruited |