NCT02412514.

Trial name or title	Public title: Intestinal humoral immunity of sequential polio vaccination schedules Scientific title: Assessing the intestinal and humoral immunity of sequential schedules of inactivated poliovirus vaccine and bivalent oral poliovirus vaccine for routine childhood immunization in Bangladesh
Methods	Design: randomised, open‐label trial
Participants	Location: Dhaka, Bangladesh Participants: healthy infants Sample size: 456 Age: 6 weeks (range: 42‐48 days)
Interventions	Arm A (I+O)OO: IPV + bOPV, bOPV and bOPV, administered at 6, 10, and 14 weeks, respectively Arm B (IOO): IPV, bOPV and bOPV, administered at 6, 10, and 14 weeks, respectively
Outcomes	Primary outcomes Change in type 1 and 3 excretion of vaccine poliovirus particles in stool one week after administration of the bOPV challenge dose (time frame: 1 week). Change in type 1, 2 and 3 poliovirus antibody responses prior to administration of poliovirus vaccinations compared to after completion of poliovirus vaccinations (time frame: 12 weeks). Secondary outcome Change in type 1 and 3 excretion of vaccine poliovirus in stool two weeks after administration of the bOPV challenge dose at 18 weeks of age.
Starting date	Start date: April 2015 Completion date: December 2015
Contact information	Sponsor: Centers for Disease Control and Prevention Collabator: International Centre for Diarrhoeal Disease Research, Bangladesh Principal Investigator: not stated
Notes	Recruitment status: completed