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. 2019 Nov 19;2019(11):CD012487. doi: 10.1002/14651858.CD012487.pub2

Summary of findings 4. Multi‐component intervention compared to no intervention for increasing standing or walking for decreasing musculoskeletal symptoms in sedentary workers.

Multi‐component intervention compared to no intervention for increasing standing or walking for decreasing musculoskeletal symptoms in sedentary workers
Patient or population: sedentary workers with musculoskeletal symptoms
 Setting: office setting
 Intervention: multi‐component intervention
 Comparison: no intervention
Outcomes Anticipated absolute effects* (95% CI) Relative effect
 (95% CI) № of participants
 (studies) Certainty of the evidence
 (GRADE) Comments
Risk with no intervention Risk with multi‐component intervention
Proportion of participants with low back pain/discomfort follow‐up short‐term 625 per 1000 581 per 1000
 (431 to 794) RR 0.93
 (0.69 to 1.27) 107
 (3 RCTs) ⊕⊕⊝⊝
 Lowa,b  
Proportion of participants with upper back pain/discomfort follow‐up short‐term 353 per 1000 311 per 1000
 (141 to 692) RR 0.88
 (0.40 to 1.96) 40
 (2 RCTs) ⊕⊕⊝⊝
 Lowa,b  
Proportion of participants with neck pain/discomfort follow‐up short‐term 623 per 1000 623 per 1000
 (473 to 822) RR 1.00
 (0.76 to 1.32) 115
 (3 RCTs) ⊕⊕⊝⊝
 Lowa,b  
Proportion of participants with shoulder pain/discomfort follow‐up short‐term 207 per 1000 172 per 1000
 (25 to 1000) RR 0.83
 (0.12 to 5.80) 66
 (2 RCTs) ⊕⊝⊝⊝
 Very lowa,b,c  
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 
 CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio.
GRADE Working Group grades of evidence.High certainty: we are very confident that the true effect lies close to that of the estimate of the effect.
 Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
 Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
 Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

aConcerns about personnel and outcome assessor blinding; downgraded one level.

bSmall sample size and wide confidence intervals; downgraded one level.

cHigh heterogeneity, I² = 69%; downgraded one level.